肠道粘液对肠道的保护依赖于菌群-凯发k8官网

肠道粘液对肠道的保护依赖于菌群
文章来源:未知 文章作者:enread 发布时间:2014-12-30 04:46 字体: [ ] 
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the quality of the 1 mucus in mice depends on the composition of 2 microbiota, reports a swedish-norwegian team of researchers from the university of gothenburg and the norwegian university of life sciences in oslo. the work, published in embo reports, suggests that bacteria in the gut affect mucus barrier properties in ways that can have implications for health and disease. "3 similar mice with subtle but stable and transmissible 4 microbiota showed unexpectedly large differences in the inner colon mucus layer. the composition of the gut microbiota has significant effects on mucus properties," says malin e.v. johansson from the university of gothenburg who led the study.
 
by sequencing the microbiota and examining the 16s ribosomal rna 5, the researchers discovered that two mouse colonies maintained in two different rooms in the same specific pathogen-free facility had different gut microbiota. they also had a mucus structure that was specific for each colony. whereas one colony developed mucus that was not 6 to bacteria, the other colony had an inner mucus layer permeable to bacteria.
 
each group of mice had a stable population of bacteria that could be 7 transmitted: the group with impenetrable mucus had increased amounts of erysipelotrichi bacteria, while the other group had higher levels of proteobacteria and tm7 bacteria in the distal colon mucus. free-living mice from the forest had mucus similar in composition to that found in mice in the non-penetrable colony. the authors also showed that the 8 composition could be 9 to a small extent through the diet.
 
"the results from the free-living mice strongly argue for the importance of a well-developed inner mucus layer that 10 separates bacteria from the host epithelium for the overall health of the mice," says johansson.
 
the different mucus properties were recreated by transplanting the microbial communities into germ-free mice. "after recolonisation of germ-free mice with the different microbiota we observed the same 11 and 12 differences in their mucus properties," added johansson.
 
mucus is our 13 barrier to our microbiota in the gut. if the mucus fails to offer a protective barrier it can allow more bacteria to come in contact with our epithelium in a way that can trigger colon inflammation. diseases such as ulcerative colitis show an increased incidence in the western world and this study emphasizes the importance of the composition of the microbiota for an impenetrable protective mucus barrier.


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1 jqfzj     
n.冒号,结肠,直肠
参考例句:
  • here,too,the colon must be followed by a dash.这里也是一样,应当在冒号后加破折号。
  • the colon is the locus of a large concentration of bacteria.结肠是大浓度的细菌所在地。
2 mezzp     
n.[pl.]胆量;内脏;adj.本能的;vt.取出内脏
参考例句:
  • it is not always necessary to gut the fish prior to freezing.冷冻鱼之前并不总是需要先把内脏掏空。
  • my immediate gut feeling was to refuse.我本能的直接反应是拒绝。
3 lgixo     
adv.遗传上
参考例句:
  • all the bees in the colony are genetically related. 同一群体的蜜蜂都有亲缘关系。
  • genetically modified foods have already arrived on american dinner tables. 经基因改造加工过的食物已端上了美国人的餐桌。 来自英汉非文学 - 生命科学 - 基因与食物
4 dbhzx     
adj.肠的;肠壁;肠道细菌
参考例句:
  • a few other conditions are in high intestinal obstruction. 其它少数情况是高位肠梗阻。 来自辞典例句
  • this complication has occasionally occurred following the use of intestinal antiseptics. 这种并发症偶而发生在使用肠道抗菌剂上。 来自辞典例句
5 01914f8eac35d7e14afa065217edd8c0     
n.基因( gene的名词复数 )
参考例句:
  • you have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因,所以能够活得很长。 来自《简明英汉词典》
  • differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学 - 生命科学 - 生物技术的世纪
6 d49df8fa1174737f8ba1c7d89c51c7f1     
adj.可穿透的
参考例句:
  • soil that is easily penetrable with a fork 能轻易下耙的土壤
  • perhaps the most aspect of this technology is that it is intellectually penetrable. 这个技术最重要的地方在于它是可以被理解贯通的。 来自互联网
7 e0cf9da8fdb32a0206b9748503b0d531     
参考例句:
  • she loved her students almost maternally. 她像母亲一样爱她的学生。
  • the resulting fetuses consisted of either mostly paternally or mostly maternally expressed genes. 这样产生的胎儿要么主要是父方的基因表达,要么主要是母方的基因表达。
8 dy5z8q     
a.细菌的
参考例句:
  • bacterial reproduction is accelerated in weightless space. 在失重的空间,细菌繁殖加快了。
  • brain lesions can be caused by bacterial infections. 大脑损伤可能由细菌感染引起。
9 b5bfb3c5c3ebc18c62afa9380ab74ba5     
已调整[制]的,被调的
参考例句:
  • he carefully modulated his voice. 他小心地压低了声音。
  • he had a plump face, lemur-like eyes, a quiet, subtle, modulated voice. 他有一张胖胖的脸,狐猴般的眼睛,以及安详、微妙和富于抑扬顿挫的嗓音。
10 zutzxq     
adv.高效率地,有能力地
参考例句:
  • the worker oils the machine to operate it more efficiently.工人给机器上油以使机器运转更有效。
  • local authorities have to learn to allocate resources efficiently.地方政府必须学会有效地分配资源。
11 itxw5     
adj.构造的,组织的,建筑(用)的
参考例句:
  • the storm caused no structural damage.风暴没有造成建筑结构方面的破坏。
  • the north american continent is made up of three great structural entities.北美大陆是由三个构造单元组成的。
12 5hmxa     
adj.为实用而设计的,具备功能的,起作用的
参考例句:
  • the telephone was out of order,but is functional now.电话刚才坏了,但现在可以用了。
  • the furniture is not fancy,just functional.这些家具不是摆着好看的,只是为了实用。
13 w4fzc     
adj.最外面的,远离中心的
参考例句:
  • he fired and hit the outermost ring of the target.他开枪射中了靶子的最外一环。
  • the outermost electron is shielded from the nucleus.原子核对最外层电子的作用受到屏蔽。
tag标签: gut mucus colon
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