精神创伤会跨代遗传吗?-凯发k8官网

精神创伤会跨代遗传吗?
文章来源:未知 文章作者:meng 发布时间:2010-09-09 02:56 字体: [ ] 
(单词翻译:双击或拖选)

in groups with high rates of posttraumatic(外伤后的) stress 2 (ptsd), such as the 3 of the 4 death camps, the adjustment problems of their children, the so-called "second generation", have received attention by researchers. studies suggested that some symptoms or personality traits(人格特质) associated with ptsd may be more common in the second generation than the general population. it has been assumed that these trans-generational effects reflected the impact of ptsd upon the parent-child relationship rather than a trait passed biologically from parent to child. however, dr. isabelle mansuy and colleagues provide new evidence in the current issue of biological 6(精神病学) that some aspects of the impact of 1 cross generations and are associated with epigenetic(后生的,外成的) changes, i.e., the regulation of the pattern of 5 expression, without changing the 7 sequence.

they found that early-life stress induced depressive-like behaviors and altered behavioral responses to aversive(反感的) environments in mice. importantly, these behavioral 8 were also found in the offspring of males subjected to early stress even though the offspring were raised normally without any stress. in parallel, the profile of dna methylation(甲基化) was altered in several 9 in the germline(生殖细胞系) (sperm) of the fathers, and in the brain and germline of their offspring.

"it is fascinating that clinical observations in humans have suggested the possibility that specific traits acquired during life and influenced by environmental factors may be transmitted across generations. it is even more challenging to think that when related to behavioral alterations, these traits could explain some psychiatric conditions in families," said dr. mansuy, lead author on this project. "our findings in mice provide a first step in this direction and suggest the 10 of epigenetic processes in such phenomenon."

"the idea that traumatic stress responses may alter the regulation of genes in the germline cells in males means that these stress effects may be passed across generations. it is 11 to think that the negative consequences of exposure to horrible life events could cross generations," commented dr. john krystal, editor of biological psychiatry. "however, one could imagine that these types of responses might prepare the offspring to cope with hostile environments. further, if environmental events can produce negative effects, one wonders whether the opposite pattern of dna methylation emerges when offspring are reared in supportive environments."

further research will be necessary to answer those questions, but these findings open a new door in the emerging field of neuroepigenetics.



点击收听单词发音收听单词发音  

1 tjizj     
n.外伤,精神创伤
参考例句:
  • counselling is helping him work through this trauma.心理辅导正帮助他面对痛苦。
  • the phobia may have its root in a childhood trauma.恐惧症可能源于童年时期的创伤。
2 et1x4     
n.紊乱,混乱;骚动,骚乱;疾病,失调
参考例句:
  • when returning back,he discovered the room to be in disorder.回家后,他发现屋子里乱七八糟。
  • it contained a vast number of letters in great disorder.里面七零八落地装着许多信件。
3 02ddbdca4c6dba0b46d9d823ed2b4b62     
幸存者,残存者,生还者( survivor的名词复数 )
参考例句:
  • the survivors were adrift in a lifeboat for six days. 幸存者在救生艇上漂流了六天。
  • survivors clinging to a raft 紧紧抓住救生筏的幸存者
4 bjxyf     
n.纳粹分子,adj.纳粹党的,纳粹的
参考例句:
  • they declare the nazi regime overthrown and sue for peace.他们宣布纳粹政权已被推翻,并出面求和。
  • nazi closes those war criminals inside their concentration camp.纳粹把那些战犯关在他们的集中营里。
5 wgkxx     
n.遗传因子,基因
参考例句:
  • a single gene may have many effects.单一基因可能具有很多种效应。
  • the targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。
6 g0jze     
n.精神病学,精神病疗法
参考例句:
  • the study appeared in the amercian science journal of psychiatry.这个研究发表在美国精神病学的杂志上。
  • a physician is someone who specializes in psychiatry.精神病专家是专门从事精神病治疗的人。
7 4u3z1l     
(缩)deoxyribonucleic acid 脱氧核糖核酸
参考例句:
  • dna is stored in the nucleus of a cell.脱氧核糖核酸储存于细胞的细胞核里。
  • gene mutations are alterations in the dna code.基因突变是指dna密码的改变。
8 c8302d4e0b3c212bc802c7294057f1cb     
n.改动( alteration的名词复数 );更改;变化;改变
参考例句:
  • any alterations should be written in neatly to the left side. 改动部分应书写清晰,插在正文的左侧。 来自《简明英汉词典》
  • gene mutations are alterations in the dna code. 基因突变是指dna 密码的改变。 来自《简明英汉词典》
9 01914f8eac35d7e14afa065217edd8c0     
n.基因( gene的名词复数 )
参考例句:
  • you have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因,所以能够活得很长。 来自《简明英汉词典》
  • differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学 - 生命科学 - 生物技术的世纪
10 e5sxz     
n.介入,干涉,干预
参考例句:
  • the government's intervention in this dispute will not help.政府对这场争论的干预不会起作用。
  • many people felt he would be hostile to the idea of foreign intervention.许多人觉得他会反对外来干预。
11 cutz30     
a.使人痛苦的
参考例句:
  • all who saw the distressing scene revolted against it. 所有看到这种悲惨景象的人都对此感到难过。
  • it is distressing to see food being wasted like this. 这样浪费粮食令人痛心。
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