animals, including humans,
1 select the
2 microbes that are the best partners and
3 them with
4 5（分泌物）, suggests a new study led by
6 university, and published november 20 in the open-access journal plos biology. the oxford team created an
7 computer model of interactions between gut microbes and the
8 (the host epithelial cell layer) of the animal gut. the model shows that beneficial microbes that are slow-growing are rapidly lost, and need to be helped by host secretions, such as specific
9, that favour the beneficial microbes over harmful ones.
the work also shows that the cost of such selectivity is low: the host only needs to use a very small amount of secretions to retain beneficial microbes that would otherwise have been lost.
"the cells of our bodies are greatly outnumbered by the microbes that live on us and, in particular, in our gut," said professor kevin foster of oxford university's department of
10, an author of the new paper. "we know that many gut microbes are highly beneficial to us, protecting us from pathogens and
11 us with
12, but quite how such a beneficial
13 relationship evolved, and how it is maintained, has been something of a mystery."
"this research highlights the importance of growth-promoting substances in our ability to control the microbes that live inside us. it shows that nutrients are more powerful when released by the host
epithelial cell（上皮细胞） layer than when coming from the food in the gut, and suggests that controlling our microbes is easier than was
14 thought."
jonas schulter, also of oxford university's department of zoology and first author of the paper, said: "the inside of our gut is rather like a war zone, with all kinds of microbes battling it out for survival and fighting over territory. our study shows that hosts only have to
15 a small quantity of substances that slightly favour beneficial microbes to tip the balance of this conflict: it means that favoured microbial species that would otherwise be lost don't just survive on the epithelial surface but expand, pushing any other strains out."
the team's simulations show that cells
16 by host epithelial selection are least likely to be lost, and instead persist longest, causing 'selectivity
17', whereby
18 tiny changes instituted by the host (in this case a very small amount of secretions of certain compounds) can be
19 to produce a large-scale effect.
the study may have wider implications than the human gut: selectivity amplification may occur in a range of other interactions between hosts and microbes, including the microbes that grow on the surface of corals and the roots of plants.
收听单词发音 
