某人类抗体使猴子免受亨德拉病毒侵扰-凯发k8官网

某人类抗体使猴子免受亨德拉病毒侵扰
文章来源:未知 文章作者:enread 发布时间:2011-10-20 03:42 字体: [ ] 
(单词翻译:双击或拖选)

a human antibody given to monkeys infected with the deadly hendra virus completely protected them from disease, according to a study published by national institutes of health (nih) scientists and their collaborators. hendra and the closely related nipah virus, both rare viruses that are part of the nih biodefense research program, target the lungs and brain and have human case 1 rates of 60 percent and more than 75 percent, respectively. these diseases in monkeys mirror what happens in humans, and the study results are cause for hope that the antibody, named m102.4, ultimately may be developed into a possible treatment for people who become infected with these viruses. in may 2010, shortly after the nih study in monkeys successfully concluded, australian health officials requested m102.4 for emergency use in a woman and her 12-year-old daughter. they had been exposed to hendra virus from an ill horse that ultimately was euthanized(安乐死) . both the woman and child survived and showed no side effects from the treatment.

"this is an important research advance that 2 how scientific discoveries emerge through a steady stepwise(逐步地) process, and how our investment in research on countermeasures for biodefense and emerging infectious diseases can help global preparedness efforts," said anthony s. fauci, m.d., director of the nih's national institute of 3 and infectious diseases (niaid).

hendra virus emerged in 1994 in australia and primarily affects horses, which can spread the disease to humans. no person-to-person transmission of hendra has been reported. nipah virus emerged in 1998 in malaysia, and also has been found in bangladesh and india. nipah appears to infect humans more easily than hendra and can be transmitted from person to person.

the niaid-supported study, which appears online in science translational medicine, involved infecting 14 african green monkeys with a 4 dose of hendra virus. twelve of the monkeys then received two treatments with m102.4, one either at 10, 24, or 72 hours after being infected, and another 48 hours later. all 12 monkeys treated with the antibody survived. the two untreated control monkeys died eight days after being infected.

the findings are the result of a series of studies carried out by different research laboratories. a group from nih's national cancer institute and the uniformed services university of the health sciences (usuhs) discovered m102.4 in 2006 and developed the antibody for use in laboratory research. usuhs and australian collaborators then developed an animal study model of m102.4 in ferrets(雪貂) infected with nipah virus; the university of texas medical branch and usuhs developed a monkey study model of hendra and nipah infection; and together with 5 from boston university and niaid's rocky mountain laboratories (rml) designed and carried out the antibody trial in biosafety level-4 (bsl-4) laboratory space at rml. because the hendra and nipah viruses are so deadly and there is no 6 7 or treatment for either of them, both viruses must be studied in maximum-containment bsl-4 laboratories.



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1 alfxt     
n.不幸,灾祸,天命
参考例句:
  • she struggle against fatality in vain.她徒然奋斗反抗宿命。
  • he began to have a growing sense of fatality.他开始有一种越来越强烈的宿命感。
2 a03402300df9f3e3716d9eb11aae5782     
给…加插图( illustrate的第三人称单数 ); 说明; 表明; (用示例、图画等)说明
参考例句:
  • this historical novel illustrates the breaking up of feudal society in microcosm. 这部历史小说是走向崩溃的封建社会的缩影。
  • alfred adler, a famous doctor, had an experience which illustrates this. 阿尔弗莱德 - 阿德勒是一位著名的医生,他有过可以说明这点的经历。 来自中级百科部分
3 8vpza     
n.(因食物、药物等而引起的)过敏症
参考例句:
  • he developed an allergy to pollen.他对花粉过敏。
  • the patient had an allergy to penicillin.该患者对青霉素过敏。
4 d3lyb     
adj.致死的;毁灭性的
参考例句:
  • a hammer can be a lethal weapon.铁锤可以是致命的武器。
  • she took a lethal amount of poison and died.她服了致命剂量的毒药死了。
5 e970f9140785518a87fc81641b7c89f7     
n.调查者,审查者( investigator的名词复数 )
参考例句:
  • this memo could be the smoking gun that investigators have been looking for. 这份备忘录可能是调查人员一直在寻找的证据。
  • the team consisted of six investigators and two secretaries. 这个团队由六个调查人员和两个秘书组成。 来自《简明英汉词典》
6 ipmzni     
adj.得到许可的v.许可,颁发执照(license的过去式和过去分词)
参考例句:
  • the new drug has not yet been licensed in the us. 这种新药尚未在美国获得许可。
  • is that gun licensed? 那支枪有持枪执照吗?
7 ki1wv     
n.牛痘苗,疫苗;adj.牛痘的,疫苗的
参考例句:
  • the polio vaccine has saved millions of lives.脊髓灰质炎疫苗挽救了数以百万计的生命。
  • she takes a vaccine against influenza every fall.她每年秋季接种流感疫苗。
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