探秘中药雷公藤的神奇效用-凯发k8官网

探秘中药雷公藤的神奇效用
文章来源:未知 文章作者:enread 发布时间:2011-03-04 01:30 字体: [ ] 
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researchers at the johns hopkins school of medicine have discovered that a natural product 1 from a traditional chinese medicinal plant commonly known as thunder god vine(雷公藤) , or lei gong teng, and used for hundreds of years to treat many conditions including rheumatoid 2(风湿性关节炎) works by blocking 3 control 4 in the cell. the report, published as a cover story of the march issue of nature chemical biology, suggests that the natural product could be a starting point for developing new anticancer drugs. "extracts of this medicinal plant have been used to treat a whole host of conditions and have been highly 5 for anti-inflammatory, immunosuppressive(免抑制疫离的) , contraceptive and antitumor activities," says jun o. liu, ph.d., a professor of pharmacology and 6 sciences at johns hopkins. "we've known about the active compound, triptolide(雷公藤内脂) , and that it stops cell growth, since 1972, but only now have we figured out what it does."

triptolide, the active ingredient purified from the plant tripterygium wilfordii hook f, has been shown in animal models to be effective against cancer, arthritis and skin 7 8. in fact, says liu, triptolide has been shown to block the growth of all 60 u.s. national cancer institute cell lines at very low doses, and even causes some of those cell lines to die. other experiments have suggested that triptolide 9 with proteins known to 10 11, which gives liu and colleagues an entry point into their research.

the team 12 tested triptolide's effect on different proteins involved with gene control by looking at how much new 13, rna and protein is made in cells. they treated hela cells with triptolide for one hour, compared treated to untreated cells and found that triptolide took much longer to have an effect on the levels of newly made proteins and dna, yet almost immediately blocked manufacture of new rna. the researchers then looked more closely at the three groups of 15 that make rna and found that low doses of triptolide blocked only one, rnapii.

but the rnapii 14 complex actually requires the assistance of several smaller clusters of proteins, according to liu, which required more investigative narrowing down. using a small gene fragment in a test tube, the researchers mixed in rnapii 16 and in some tubes included triptolide and some not to see which combinations resulted in manufacture of new rna. every combination of proteins that included a cluster called tfiih stopped working in the presence of triptolide.

but again, tfiih is made of 10 individual proteins, many of which, according to liu, have distinct and testable activities. using information already known about these proteins and testing the rest to see if triptolide would alter their behaviors, the research team finally found that triptolide directly 18 to and blocks the 19 activity of one of the 10, the xpb protein.

"we were fairly certain it was xpb because other researchers had found triptolide to 17 to an unknown protein of the same size, but they weren't able to identify it," says liu. "

to convince themselves that the interaction between triplotide and xpb is what stops cells from growing, the researchers made 12 chemicals related to triplotide with a wide range of activity and treated hela cells with each of the 12 chemicals at several different doses. by both counting cells and testing xpb activity levels, the team found that the two correlate; chemicals that were better at decreasing xpb activity were also better at stopping cell growth and 20 versa.

"triptolide's general ability to stop rnapii activity explains its anti-inflammatory and anticancer effects," says liu. "and its behavior has important additional implications for 21 the resistance that some cancer cells develop to certain anticancer drugs. we're eager to study it further to see what it can do for future cancer therapy."



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1 bqmztd     
adj.与世隔绝的
参考例句:
  • his bad behaviour was just an isolated incident. 他的不良行为只是个别事件。
  • patients with the disease should be isolated. 这种病的患者应予以隔离。
2 xeyye     
n.关节炎
参考例句:
  • rheumatoid arthritis has also been linked with the virus.风湿性关节炎也与这种病毒有关。
  • he spent three months in the hospital with acute rheumatic arthritis.他患急性风湿性关节炎,在医院住了三个月。
3 wgkxx     
n.遗传因子,基因
参考例句:
  • a single gene may have many effects.单一基因可能具有很多种效应。
  • the targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。
4 cadxb     
n.(总称)机械,机器;机构
参考例句:
  • has the machinery been put up ready for the broadcast?广播器材安装完毕了吗?
  • machinery ought to be well maintained all the time.机器应该随时注意维护。
5 b67508c0ca90664fe666700495cd0226     
v.称赞,赞美( laud的过去式和过去分词 )
参考例句:
  • they lauded the former president as a hero. 他们颂扬前总统为英雄。 来自辞典例句
  • the nervy feats of the mountaineers were lauded. 登山者有勇气的壮举受到赞美。 来自辞典例句
6 me9xh     
adj.分子的;克分子的
参考例句:
  • the research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • for the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
7 xqbzg     
n.移植,嫁接,艰苦工作,贪污;v.移植,嫁接
参考例句:
  • i am having a skin graft on my arm soon.我马上就要接受手臂的皮肤移植手术。
  • the minister became rich through graft.这位部长透过贪污受贿致富。
8 fvpxp     
n.拒绝,被拒,抛弃,被弃
参考例句:
  • he decided not to approach her for fear of rejection.他因怕遭拒绝决定不再去找她。
  • the rejection plunged her into the dark depths of despair.遭到拒绝使她陷入了绝望的深渊。
9 ab8163b252fe52454ada963fa857f890     
vi. 妨碍,冲突,干涉
参考例句:
  • the noise interferes with my work. 这噪音妨碍我的工作。
  • that interferes with my plan. 那干扰了我的计划。
10 uj2y0     
vt.使活动起来,使开始起作用
参考例句:
  • we must activate the youth to study.我们要激励青年去学习。
  • these push buttons can activate the elevator.这些按钮能启动电梯。
11 01914f8eac35d7e14afa065217edd8c0     
n.基因( gene的名词复数 )
参考例句:
  • you have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因,所以能够活得很长。 来自《简明英汉词典》
  • differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学 - 生命科学 - 生物技术的世纪
12 7qhwn     
adv.有系统地
参考例句:
  • this government has systematically run down public services since it took office.这一屆政府自上台以来系统地削减了公共服务。
  • the rainforest is being systematically destroyed.雨林正被系统地毀灭。
13 4u3z1l     
(缩)deoxyribonucleic acid 脱氧核糖核酸
参考例句:
  • dna is stored in the nucleus of a cell.脱氧核糖核酸储存于细胞的细胞核里。
  • gene mutations are alterations in the dna code.基因突变是指dna密码的改变。
14 cpozf     
n.酵素,酶
参考例句:
  • above a certain temperature,the enzyme molecule will become unfolded.超过一定温度,酶分子将会展开。
  • an enzyme that dissolves the fibrin of blood clots.能溶解血凝块中的纤维的酶。
15 7881ad8ce9c83424f7874e70266ed2d8     
n. 酶,酵素
参考例句:
  • it was said that washing powders containing enzymes remove stains more efficiently. 据说加酶洗衣粉除污更有效。
  • among the enzymes which are particularly effective are pepsin, papain. 在酶当中特别有效的是胃朊酶、木瓜酶。
16 4725dcf446a342f1473a8228e42dfa48     
(机器、设备等的)构成要素,零件,成分; 成分( component的名词复数 ); [物理化学]组分; [数学]分量; (混合物的)组成部分
参考例句:
  • the components of a machine 机器部件
  • our chemistry teacher often reduces a compound to its components in lab. 在实验室中化学老师常把化合物分解为各种成分。
17 vt8zi     
vt.捆,包扎;装订;约束;使凝固;vi.变硬
参考例句:
  • i will let the waiter bind up the parcel for you.我让服务生帮你把包裹包起来。
  • he wants a shirt that does not bind him.他要一件不使他觉得过紧的衬衫。
18 c1d4f6440575ef07da0adc7e8adbb66c     
v.约束( bind的第三人称单数 );装订;捆绑;(用长布条)缠绕
参考例句:
  • frost binds the soil. 霜使土壤凝结。 来自《简明英汉词典》
  • stones and cement binds strongly. 石头和水泥凝固得很牢。 来自《简明英汉词典》
19 bd3713b8a9001c96e240f712d69d0355     
adj. 酶的
参考例句:
  • this chromoprotein has also been endowed with enzymatic properties. 这种色素蛋白也具有酶的特性。
  • it is of profound interest to elucidate the enzymatic activities in soil. 阐明土壤中酶的活性是有深远意义的。
20 nu0zq     
n.坏事;恶习;[pl.]台钳,老虎钳;adj.副的
参考例句:
  • he guarded himself against vice.他避免染上坏习惯。
  • they are sunk in the depth of vice.他们堕入了罪恶的深渊。
21 098f8dc61efcabdcdd7f52cc484b51a8     
v.设法克服或避免(某事物),回避( circumvent的现在分词 );绕过,绕行,绕道旅行
参考例句:
  • they found a way of circumventing the law. 他们找到了规避法律的途径。
  • this viewpoint sees the multinational corporation as capable of circumventing or subverting national objectives and policies. 这种观点认为,跨国公司能够遏制和破坏国家的目标和政策。 来自辞典例句
tag标签: plant chinese molecular
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