脊髓液化验可区别莱姆病与慢性疲劳综合征-凯发k8官网

脊髓液化验可区别莱姆病与慢性疲劳综合征
文章来源:未知 文章作者:enread 发布时间:2011-02-25 01:03 字体: [ ] 
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patients who suffer from neurologic(神经病学的) post treatment lyme disease (nptls) and those with the 1 2 3 report similar symptoms. however unique proteins discovered in 4 fluid can distinguish those two groups from one another and also from people in normal health, according to new research conducted by a team led by steven e. schutzer, md, of the university of medicine and dentistry of new 5 – new jersey medical school, and richard d. smith, ph.d., of pacific northwest national laboratory. this finding, published in the journal plos one (february 23, 2011), also suggests that both conditions involve the central nervous system and that protein abnormalities in the central nervous system are causes and/or effects of both conditions. the 6 7 spinal fluid from three groups of people. one group consisted of 43 patients who fulfilled the clinical 8 for chronic fatigue syndrome (cfs). the second group consisted of 25 patients who had been diagnosed with, and treated for, lyme disease but did not completely recover. the third group consisted of 11 healthy control subjects. "spinal fluid is like a liquid window to the brain," says dr. schutzer. by studying the spinal fluid, the research team hoped to find abnormalities that could be used as markers of each condition and could lead to improvements in 9 and treatment.

taking advantage of 10 unavailable methods for 11 analysis of spinal fluid, the investigators analyzed the fluid by means of high powered mass spectrometry(光谱测定法) and special protein separation techniques. they found that each group had more than 2,500 12 proteins. the research team discovered that there were 738 proteins that were identified only in cfs but not in either healthy normal controls or patients with nptls and 692 proteins found only in the nptls patients. previously there had been no available candidate biomarkers to distinguish between the two 13(综合症) , nor even strong evidence that the central nervous system is involved in those conditions.

this research represents the most comprehensive analysis of the complete csf proteome(蛋白质组) (collection of proteins) to date for both chronic fatigue syndrome and neurologic post treatment lyme disease (nptls). prior to this study, many scientists believed that cfs was an umbrella category that included nptls. however these results call those previous suppositions into question.

according to dr. schutzer, spinal fluid proteins can likely be used as a marker of disease, and this study provides a starting point for research in that area. "one next step will be to find the best biomarkers that will give 14 diagnostic results," he says. "in addition, if a protein pathway is found to influence either disease, scientists could then develop treatments to target that particular pathway."

"newer techniques that are being developed by the team will allow researchers to dig even deeper and get more information for these and other neurologic diseases," says dr. smith. "these exciting findings are the tip of our research iceberg(冰山) "



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1 bo9zl     
adj.(疾病)长期未愈的,慢性的;极坏的
参考例句:
  • famine differs from chronic malnutrition.饥荒不同于慢性营养不良。
  • chronic poisoning may lead to death from inanition.慢性中毒也可能由虚弱导致死亡。
2 phvzv     
n.疲劳,劳累
参考例句:
  • the old lady can't bear the fatigue of a long journey.这位老妇人不能忍受长途旅行的疲劳。
  • i have got over my weakness and fatigue.我已从虚弱和疲劳中恢复过来了。
3 uqbwu     
n.综合病症;并存特性
参考例句:
  • the institute says that an unidentified virus is to blame for the syndrome. 该研究所表示,引起这种综合症的是一种尚未确认的病毒。
  • results indicated that 11 fetuses had down syndrome. 结果表明有11个胎儿患有唐氏综合征。
4 kfczs     
adj.针的,尖刺的,尖刺状突起的;adj.脊骨的,脊髓的
参考例句:
  • after three days in japan,the spinal column becomes extraordinarily flexible.在日本三天,就已经使脊椎骨变得富有弹性了。
  • your spinal column is made up of 24 movable vertebrae.你的脊柱由24个活动的脊椎骨构成。
5 lp5zzo     
n.运动衫
参考例句:
  • he wears a cotton jersey when he plays football.他穿运动衫踢足球。
  • they were dressed alike in blue jersey and knickers.他们穿着一致,都是蓝色的运动衫和灯笼短裤。
6 e970f9140785518a87fc81641b7c89f7     
n.调查者,审查者( investigator的名词复数 )
参考例句:
  • this memo could be the smoking gun that investigators have been looking for. 这份备忘录可能是调查人员一直在寻找的证据。
  • the team consisted of six investigators and two secretaries. 这个团队由六个调查人员和两个秘书组成。 来自《简明英汉词典》
7 483f1acae53789fbee273a644fdcda80     
v.分析( analyze的过去式和过去分词 );分解;解释;对…进行心理分析
参考例句:
  • the doctors analyzed the blood sample for anemia. 医生们分析了贫血的血样。 来自《简明英汉词典》
  • the young man did not analyze the process of his captivation and enrapturement, for love to him was a mystery and could not be analyzed. 这年轻人没有分析自己蛊惑著迷的过程,因为对他来说,爱是个不可分析的迷。 来自《简明英汉词典》
8 vafyc     
n.标准
参考例句:
  • the main criterion is value for money.主要的标准是钱要用得划算。
  • there are strict criteria for inclusion in the competition.参赛的标准很严格。
9 gvpxc     
n.诊断,诊断结果,调查分析,判断
参考例句:
  • his symptoms gave no obvious pointer to a possible diagnosis.他的症状无法作出明确的诊断。
  • the engineer made a complete diagnosis of the bridge's collapse.工程师对桥的倒塌做一次彻底的调查分析。
10 bkzzzc     
adv.以前,先前(地)
参考例句:
  • the bicycle tyre blew out at a previously damaged point.自行车胎在以前损坏过的地方又爆开了。
  • let me digress for a moment and explain what had happened previously.让我岔开一会儿,解释原先发生了什么。
11 xunzms     
adj.详细的,详尽的,极注意细节的,完全的
参考例句:
  • he had made a detailed study of the terrain.他对地形作了缜密的研究。
  • a detailed list of our publications is available on request.我们的出版物有一份详细的目录备索。
12 tuxzmd     
adj.可发觉的;可查明的
参考例句:
  • the noise is barely detectable by the human ear.人的耳朵几乎是察觉不到这种噪音的。
  • the inflection point at this ph is barely detectable.在此ph值下,拐点不易发现。
13 300fdb3af54a410e55b4108acba05633     
n.综合征( syndrome的名词复数 );(某种条件下有共同特征的)一系列表现(事件、举动等)
参考例句:
  • other agents can cause similar syndromes. 其它病原也可引起相似的综合症。 来自辞典例句
  • they have pointed out the similarities of the sprue syndromes in man and tge. 他们强调了人的鹅口疮综合症和tge的共同点。 来自辞典例句
14 tyjyw     
adj.最后的,结论的;确凿的,消除怀疑的
参考例句:
  • they produced some fairly conclusive evidence.他们提供了一些相当确凿的证据。
  • franklin did not believe that the french tests were conclusive.富兰克林不相信这个法国人的实验是结论性的。
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