服用少量阿司匹林可提高结直肠癌检测正确率-凯发k8官网

服用少量阿司匹林可提高结直肠癌检测正确率
文章来源:未知 文章作者:meng 发布时间:2010-12-08 03:22 字体: [ ] 
(单词翻译:双击或拖选)

use of low-dose 1 prior to a newer type of fecal(排泄物的,残渣的) occult blood(潜隐血) test is associated with a higher sensitivity for detecting advanced colorectal(结肠直肠的) tumors, compared to no aspirin use, according to a study in the december 8 issue of jama. "screening for colorectal cancer (crc) and its 3 by fecal occult blood tests (fobts), which has been shown to reduce crc incidence and mortality in randomized trials, is widely recommended and 4 in an increasing number of countries. screening is mostly done in age groups in which use of low-dose aspirin for primary or secondary prevention of cardiovascular disease(冠心病) is increasingly common. use of low-dose aspirin increases the likelihood of gastrointestinal(胃肠的) bleeding, especially upper gastrointestinal bleeding. because of the increased risk of bleeding from sources other than colorectal neoplasms(肿瘤,赘生物) [tumors], concerns have been raised regarding possible 5 effects on specificity of fobt-based screening for crc," according to background information in the article. potential false-positive test results due to increased risk of upper gastrointestinal bleeding are expected to be of less concern for increasingly available immunochemical fobts (ifobts; a type of test to check for blood in the stool), but evidence is 6 about the performance of ifobts for patients who use low-dose aspirin.

hermann brenner, m.d., m.p.h., of the german cancer research center, heidelberg, germany, and colleagues assessed the association of use of low-dose aspirin with performance of 2 ifobts in a large sample of women and men who underwent crc screening. the study, conducted from 2005 through 2009, included 1,979 patients (average age, 62.1 years): 233 regular users of low-dose aspirin (167 men, 67 women) and 1,746 who never used low-dose aspirin (809 men, 937 women). the researchers 7 measures of sensitivity and specificity in detecting advanced colorectal neoplasms (colorectal cancer or advanced adenoma [a 2 that is not cancer]) with 2 8 ifobts (hemoglobin test and hemoglobin-haptoglobin [a protein] test).

advanced neoplasms were found in 24 users (10.3 percent) and 181 nonusers (10.4 percent) of low-dose aspirin. the researchers found that for the hemoglobin test, sensitivity was 70.8 percent for low-dose aspirin users compared with 35.9 percent for nonusers; specificity was 85.7 percent for users compared with 89.2 percent for nonusers. for the hemoglobin-haptoglobin test, sensitivity was 58.3 percent for users compared with 32 percent for non-users and specificity was 85.7 percent for users compared with 91.1 percent for nonusers.

"we provide a 9 comparison of the diagnostic performance of 2 quantitative ifobts among users and non-users of low-dose aspirin in the target population for crc screening. for both tests, sensitivity was markedly higher, while specificity was slightly lower among users of low-dose aspirin compared with nonusers," the authors write.

"… our study strongly suggests that use of low-dose aspirin does not 10(妨碍,束缚) testing for fecal occult blood by immunochemical tests. on the contrary, our findings raise the hypothesis that test performance may be enhanced by temporary use of low-dose aspirin, a hypothesis that needs replication in larger samples and followed up in further research, ideally including randomized trials and different types of fobts."



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1 4yszpm     
n.阿司匹林
参考例句:
  • the aspirin seems to quiet the headache.阿司匹林似乎使头痛减轻了。
  • she went into a chemist's and bought some aspirin.她进了一家药店,买了些阿司匹林。
2 fkxzm     
n.(肿)瘤,肿块(英)tumour
参考例句:
  • he was died of a malignant tumor.他死于恶性肿瘤。
  • the surgeons irradiated the tumor.外科医生用x射线照射那个肿瘤。
3 5e19fce64ab14f5a4b5c8687640c2593     
n.先驱( precursor的名词复数 );先行者;先兆;初期形式
参考例句:
  • phenyl (or polyphenyl) substituted epoxides serve as excellent precursors to phenyl (or diphenyl) carbenes. 某些苯代(或多苯)环氧乙烷是制取带苯环(或二苯)碳烯的极好原料。 来自辞典例句
  • note the presence of megakaryocytes, erythroid islands, and granulocytic precursors. 可见巨核细胞,红细胞岛和粒细胞前体细胞。 来自互联网
4 tz2zxa     
adj.应用的;v.应用,适用
参考例句:
  • she plans to take a course in applied linguistics.她打算学习应用语言学课程。
  • this cream is best applied to the face at night.这种乳霜最好晚上擦脸用。
5 5xbzs     
adj.不利的;有害的;敌对的,不友好的
参考例句:
  • he is adverse to going abroad.他反对出国。
  • the improper use of medicine could lead to severe adverse reactions.用药不当会产生严重的不良反应。
6 sfjzg     
adj.稀疏的,稀稀落落的,薄的
参考例句:
  • the teacher's house is in the suburb where the houses are sparse.老师的家在郊区,那里稀稀拉拉有几处房子。
  • the sparse vegetation will only feed a small population of animals.稀疏的植物只够喂养少量的动物。
7 483f1acae53789fbee273a644fdcda80     
v.分析( analyze的过去式和过去分词 );分解;解释;对…进行心理分析
参考例句:
  • the doctors analyzed the blood sample for anemia. 医生们分析了贫血的血样。 来自《简明英汉词典》
  • the young man did not analyze the process of his captivation and enrapturement, for love to him was a mystery and could not be analyzed. 这年轻人没有分析自己蛊惑著迷的过程,因为对他来说,爱是个不可分析的迷。 来自《简明英汉词典》
8 tcpyg     
adj.数量的,定量的
参考例句:
  • he said it was only a quantitative difference.他说这仅仅是数量上的差别。
  • we need to do some quantitative analysis of the drugs.我们对药物要进行定量分析。
9 xunzms     
adj.详细的,详尽的,极注意细节的,完全的
参考例句:
  • he had made a detailed study of the terrain.他对地形作了缜密的研究。
  • a detailed list of our publications is available on request.我们的出版物有一份详细的目录备索。
10 oygyk     
vt.妨碍,束缚,限制;n.(有盖的)大篮子
参考例句:
  • there are some apples in a picnic hamper.在野餐用的大篮子里有许多苹果。
  • the emergence of such problems seriously hamper the development of enterprises.这些问题的出现严重阻碍了企业的发展。
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