亨廷顿氏舞蹈病治疗研究取得重大突破-凯发k8官网

亨廷顿氏舞蹈病治疗研究取得重大突破
文章来源:未知 文章作者:meng 发布时间:2010-07-30 05:56 字体: [ ] 
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scientists at the 1 institute for age research have discovered that a particular family of 2(酶) are involved in the 3(分解,故障) of proteins that modify the production of 4 fragments that lead to the pathology(病理学) of huntington's disease. these enzymes, matrix metalloproteinases(金属蛋白酶) (mmps), provide new targets for drug therapies for the disease – targets that have already been shown to respond to cancer drugs currently in clinical development. results of the research, from the laboratories of buck 5 members lisa ellerby, ph.d. and robert hughes, ph.d., appear as the cover story in the july 29, 2010 edition of neuron. huntington's disease (hd) is an 6 progressive neurodegenerative(神经变性的) 8 9 which affects motor 10 and leads to 11 decline and dementia(痴呆) . symptoms usually begin to occur in middle age; patients are often totally incapacitated(丧失能力) prior to death. the worldwide prevalence of hd is 5-10 cases per 100,000 people; the rate of occurrence is highest in peoples of western european descent.

the disease stems from a 12 in the huntingtin 7, located on human 13 four. the mutation causes abnormalities in the huntingtin protein (mutanthtt, or mhtt). the pathology of hd is accelerated when mhtt is cut into smaller, highly toxic fragments via various 14 activities. dr. ellerby said to date, scientific 15 into how those fragments are cut have focused primarily on caspases(凋亡蛋白酶) , a family of intracellular(细胞内的) proteins that 16 cell death, and calpains(钙激活酶) , enzymes regulated by the concentration of 17 ions. the buck institute study involved proteases, various enzymes that 18 the breakdown of proteins in reaction to water. dr. ellerby said this research marks the first time all of the 514 different types of proteases found in humans were individually screened in cell culture to see how they affect mhtt proteolysis(蛋白质水解) . buck institute researchers identified 11 proteases that, when 19, reduced the accumulation of toxic fragments associated with hd.

four of the proteases belong to a family called matrix metalloproteinases (mmp), a class of enzymes already involved in drug development, dr. ellerby said. "we've found a target that has known drugs for cancer treatment that could possibly have significance for hd," added dr. ellerby. "mmps are also involved in stroke, inflammation and many neurological processes; we expect a lot of scientific attention to now be focused on this important class of proteases," she said.

results involving mmps were verified in mouse models of hd, dr. ellerby said. in collaborative(合作的,协作的) studies with dr. juan botas at baylor college of medicine in houston, researchers found that homologs(同系物) of mmps suppressed hd-induced neuronal dysfunction(功能紊乱,机能障碍) in fruit flies. "the next step in this research will be to test some of the mmp inhibitor(抑制剂) drugs as a potential treatment in hd mouse models," said dr. ellerby. "we'll also be crossing mice that no longer have particular mmps with those who have hd to see what effect that has on offspring," she said.



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1 esky8     
n.雄鹿,雄兔;v.马离地跳跃
参考例句:
  • the boy bent curiously to the skeleton of the buck.这个男孩好奇地弯下身去看鹿的骸骨。
  • the female deer attracts the buck with high-pitched sounds.雌鹿以尖声吸引雄鹿。
2 7881ad8ce9c83424f7874e70266ed2d8     
n. 酶,酵素
参考例句:
  • it was said that washing powders containing enzymes remove stains more efficiently. 据说加酶洗衣粉除污更有效。
  • among the enzymes which are particularly effective are pepsin, papain. 在酶当中特别有效的是胃朊酶、木瓜酶。
3 cs0yx     
n.垮,衰竭;损坏,故障,倒塌
参考例句:
  • she suffered a nervous breakdown.她患神经衰弱。
  • the plane had a breakdown in the air,but it was fortunately removed by the ace pilot.飞机在空中发生了故障,但幸运的是被王牌驾驶员排除了。
4 inswc     
adj.有毒的,因中毒引起的
参考例句:
  • the factory had accidentally released a quantity of toxic waste into the sea.这家工厂意外泄漏大量有毒废物到海中。
  • there is a risk that toxic chemicals might be blasted into the atmosphere.爆炸后有毒化学物质可能会进入大气层。
5 hhkzk     
n.才能;学院,系;(学院或系的)全体教学人员
参考例句:
  • he has a great faculty for learning foreign languages.他有学习外语的天赋。
  • he has the faculty of saying the right thing at the right time.他有在恰当的时候说恰当的话的才智。
6 incurable     
adj.不能医治的,不能矫正的,无救的;n.不治的病人,无救的人
参考例句:
  • all three babies were born with an incurable heart condition.三个婴儿都有不可治瘉的先天性心脏病。
  • he has an incurable and widespread nepotism.他们有不可救药的,到处蔓延的裙带主义。
7 wgkxx     
n.遗传因子,基因
参考例句:
  • a single gene may have many effects.单一基因可能具有很多种效应。
  • the targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。
8 pgixp     
adj.遗传的,遗传学的
参考例句:
  • it's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
9 et1x4     
n.紊乱,混乱;骚动,骚乱;疾病,失调
参考例句:
  • when returning back,he discovered the room to be in disorder.回家后,他发现屋子里乱七八糟。
  • it contained a vast number of letters in great disorder.里面七零八落地装着许多信件。
10 ho8zt     
n.协调,协作
参考例句:
  • gymnastics is a sport that requires a considerable level of coordination.体操是一项需要高协调性的运动。
  • the perfect coordination of the dancers and singers added a rhythmic charm to the performance.舞蹈演员和歌手们配合得很好,使演出更具魅力。
11 uqwz0     
adj.认知的,认识的,有感知的
参考例句:
  • as children grow older,their cognitive processes become sharper.孩子们越长越大,他们的认知过程变得更为敏锐。
  • the cognitive psychologist is like the tinker who wants to know how a clock works.认知心理学者倒很像一个需要通晓钟表如何运转的钟表修理匠。
12 t1pym     
n.变化,变异,转变
参考例句:
  • people who have this mutation need less sleep than others.有这种突变的人需要的睡眠比其他人少。
  • so far the discussion has centered entirely around mutation in the strict sense.到目前为止,严格来讲,讨论完全集中于围绕突变问题上。
13 7ruzx     
n.染色体
参考例句:
  • chromosome material with exhibits of such behaviour is called heterochromatin.表现这种现象的染色体物质叫做异染色质。
  • a segment of the chromosome may become lost,resulting in a deletion.染色体的一个片段可能会丢失,结果产生染色体的缺失。
14 me9xh     
adj.分子的;克分子的
参考例句:
  • the research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • for the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
15 5da7eb4247add5dbd5776c9c0b38460a     
n.问题( query的名词复数 );疑问;询问;问号v.质疑,对…表示疑问( query的第三人称单数 );询问
参考例句:
  • our assistants will be happy to answer your queries. 我们的助理很乐意回答诸位的问题。
  • her queries were rhetorical,and best ignored. 她的质问只不过是说说而已,最好不予理睬。 来自《简明英汉词典》
16 ycjxl     
vi.调解,斡旋;vt.经调解解决;经斡旋促成
参考例句:
  • the state must mediate the struggle for water resources.政府必须通过调解来解决对水资源的争夺。
  • they may be able to mediate between parties with different interests.他们也许能在不同利益政党之间进行斡旋。
17 sndzy     
n.钙(化学符号ca)
参考例句:
  • we need calcium to make bones.我们需要钙来壮骨。
  • calcium is found most abundantly in milk.奶含钙最丰富。
18 btiyv     
v.催化
参考例句:
  • they are highly specific for the reactions that they catalyze.它们对被它们催化的反应有很强的专一性。
  • they are highly specific for the reactions that they catalyze.它们对被它们催化的反应有很强的专一性。
19 fqvz0i     
a.拘谨的,拘束的
参考例句:
  • boys are often more inhibited than girls about discussing their problems. 男孩子往往不如女孩子敢于谈论自己的问题。
  • having been laughed at for his lameness,the boy became shy and inhibited. 那男孩因跛脚被人讥笑,变得羞怯而压抑。
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