可导致乳糜泻的蛋白质碎片被发现-凯发k8官网

可导致乳糜泻的蛋白质碎片被发现
文章来源:未知 文章作者:meng 发布时间:2010-07-23 02:34 字体: [ ] 
(单词翻译:双击或拖选)

walter and eliza hall institute scientists have identified the three protein fragments that make gluten(面筋,麸质) - the main protein in wheat, rye(黑麦) and 1(大麦)2 to people with coeliac disease(乳糜泻) . their discovery opens the way for a new generation of diagnostics, treatments, prevention strategies and food tests for the millions of people worldwide with coeliac disease.

when people with coeliac disease eat products containing gluten their body's immune response is switched on and the 3 of the small 4(小肠) is damaged, 5 their ability to absorb 6. the disease is currently treated by 7 removing gluten from the patient's diet.

dr bob anderson, head of the walter and eliza hall institute's coeliac disease research laboratory, said it had been 60 years since gluten was discovered to be the environmental cause of coeliac disease.

"in the years since, the holy grail in coeliac disease research has been to identify the toxic peptide(缩氨酸) 8 of gluten; and that's what we've done," dr anderson said.

the research, done in 9 with dr jason tye-din, dr james dromey, dr stuart mannering, dr jessica stewart and dr tim beissbarth from the institute as well as professor jamie rossjohn at monash university and professor jim mccluskey at the university of melbourne, is published in today's issue of the international journal science translational medicine.

the study was started by professor anderson nine years ago and has involved researchers in australia and the uk as well as more than 200 coeliac disease patients.

the patients, recruited through the coeliac society of victoria and the coeliac clinic at john radcliffe hospital, uk, ate bread, rye muffins or boiled barley. six days later, blood samples were taken to measure the strength of the patients' immune responses to 2700 different gluten fragments. the responses identified 90 fragments as causing some level of immune reaction, but three gluten fragments (peptides) were revealed as being particularly toxic.

"these three components account for the majority of the immune response to gluten that is observed in people with coeliac disease," dr anderson said.

this knowledge has already been used by melbourne-based biotech company, nexpep pty ltd, to develop a 'peptide-based' immunotherapy(免疫疗法) that aims to desensitise people with coeliac disease to the toxic effects of gluten. nexpep's phase 1 trials of the therapy were completed in june and final results are expected in coming months.

the immunotherapy works by exposing people with coeliac disease to small amounts of the three toxic peptides and is based upon the same principles as desensitisation(退敏感作用) for 10.

dr anderson said although coeliac disease could be managed with a gluten-free diet, 11 with(符合,遵守) the diet is often challenging and nearly half the people on the diet still have 12(剩余的,残留的) damage to their small intestine. "consequently, the immunotherapy and three other drugs are under development to help people with coeliac disease."



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1 2dqyq     
n.大麦,大麦粒
参考例句:
  • they looked out across the fields of waving barley.他们朝田里望去,只见大麦随风摇摆。
  • he cropped several acres with barley.他种了几英亩大麦。
2 inswc     
adj.有毒的,因中毒引起的
参考例句:
  • the factory had accidentally released a quantity of toxic waste into the sea.这家工厂意外泄漏大量有毒废物到海中。
  • there is a risk that toxic chemicals might be blasted into the atmosphere.爆炸后有毒化学物质可能会进入大气层。
3 kpgzto     
n.衬里,衬料
参考例句:
  • the lining of my coat is torn.我的外套衬里破了。
  • moss makes an attractive lining to wire baskets.用苔藓垫在铁丝篮里很漂亮。
4 rbpzy     
adj.内部的;国内的;n.肠
参考例句:
  • this vitamin is absorbed through the walls of the small intestine.这种维生素通过小肠壁被吸收。
  • the service productivity is the function,including external efficiency,intestine efficiency and capacity efficiency.服务业的生产率是一个包含有外部效率、内部效率和能力效率的函数。
5 8bacf6f47ad97606aa653cf73b51b2da     
妨碍,束缚,限制( hamper的现在分词 )
参考例句:
  • so fraud on cows and development aid is seriously hampering growth. 因此在牛问题上和发展补助上的诈骗严重阻碍了发展。
  • short-termism, carbon-trading, disputing the science-are hampering the implementation of direct economically-led objectives. 短效主义,出售二氧化碳,进行科学辩论,这些都不利于实现以经济为主导的直接目标。
6 6a1e1ed248a3ac49744c39cc962fb607     
n.(食品或化学品)营养物,营养品( nutrient的名词复数 )
参考例句:
  • a lack of essential nutrients 基本营养的缺乏
  • nutrients are absorbed into the bloodstream. 营养素被吸收进血液。 来自《简明英汉词典》
7 kluzuu     
adv.永恒地,永久地,固定不变地
参考例句:
  • the accident left him permanently scarred.那次事故给他留下了永久的伤疤。
  • the ship is now permanently moored on the thames in london.该船现在永久地停泊在伦敦泰晤士河边。
8 4725dcf446a342f1473a8228e42dfa48     
(机器、设备等的)构成要素,零件,成分; 成分( component的名词复数 ); [物理化学]组分; [数学]分量; (混合物的)组成部分
参考例句:
  • the components of a machine 机器部件
  • our chemistry teacher often reduces a compound to its components in lab. 在实验室中化学老师常把化合物分解为各种成分。
9 bw7yd     
n.合作,协作;勾结
参考例句:
  • the two companies are working in close collaboration each other.这两家公司密切合作。
  • he was shot for collaboration with the enemy.他因通敌而被枪毙了。
10 2c527dd68e63f119442f4352f2a0b950     
n.[医]过敏症;[口]厌恶,反感;(对食物、花粉、虫咬等的)过敏症( allergy的名词复数 );变态反应,变应性
参考例句:
  • food allergies can result in an enormous variety of different symptoms. 食物过敏会引发很多不同的症状。 来自辞典例句
  • let us, however, examine one of the most common allergies; hayfever. 现在让我们来看看最常见的变态反应的一种--枯草热。 来自辞典例句
11 zxyzx     
n.顺从;服从;附和;屈从
参考例句:
  • i was surprised by his compliance with these terms.我对他竟然依从了这些条件而感到吃惊。
  • she gave up the idea in compliance with his desire.她顺从他的愿望而放弃自己的主意。
12 swcxl     
adj.复播复映追加时间;存留下来的,剩余的
参考例句:
  • there are still a few residual problems with the computer program.电脑程序还有一些残留问题。
  • the resulting residual chromatism is known as secondary spectrum.所得到的剩余色差叫做二次光谱。
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