研究人员发现可调节人体免疫系统的基因调节器-凯发k8官网

研究人员发现可调节人体免疫系统的基因调节器
文章来源:未知 文章作者:meng 发布时间:2010-07-02 03:18 字体: [ ] 
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researchers at oregon state university and the california institute of technology have discovered that a 2 regulator which is critical to many life functions also plays a key role in the formation of "t cells," a type of white blood cell that's important in immune function. the discovery, to be announced friday in the journal science, suggests that some types of immune function might be influenced by manipulation(操作,处理) of this genetic regulator. this could be a target for drug development, and could open the door to new immune system-based therapies for everything from diseases of t cells, such as hiv/aids, to autoimmune 3 and 4(过敏) .

other aspects of the research could be of interest to scientists trying to re-program cells to perform different functions, which is the basis of stem cell research.

the genetic regulator, or transcription factor, is called ctip2, and it's also known as bcl11b. it's a protein that controls 1 "expression," or what aspects of a cell's genetic code will be turned on and which will be left silent. discovered at osu in 2000, ctip2 has in recent years been found to be a master regulator of gene expression, controlling tissue formation in organs as diverse as tooth 5(搪瓷,珐琅) , brain cells, skin, and t cells.

"ctip2 is so important to various life functions that laboratory mice lacking this gene die within a few hours after birth," said mark leid, a professor and assistant dean in the osu college of 6. "ctip2 is not expressed in every cell, but plays essential roles in several different organs. the new finding about its relationship to early events in t cell formation may be of substantial interest to immunologists and clinicians alike."

t cells are important players in what's called the "adaptive" immune system, or the ability of an organism to mount an attack against a new 7, fight it off and then provide full or partial 8 to it in the future.

ctip2 helps regulate the complicated process that ends up creating t cells. depending on the stage of development when it's knocked out, this can result either in t cells not being formed, or different kinds of cells being formed – something that would be of significant interest to researchers who are trying to re-program cells to perform different functions.

part of what's 9 about ctip2, researchers say, is the range of seemingly separate yet critical functions it performs. ctip2 is essential in the creation of teeth, the formation of skin, and t cells. in all of these cells and tissues, ctip2 is involved in 10 of one cell type into another, more mature cell. osu researchers have also found that the amount of ctip2 expressed by certain cancer cells is correlated with the aggressiveness of tumors, which may be helpful for diagnostic purposes.

every cell in the human body, and that of plants and other animals, contains the entire "genome," or genetic 11 of life of the particular organism. research on genetic regulators has been of increasing interest in recent years because these proteins hold the key to which 12 are expressed, instructing one cell to become a brain cell while another is directed to become a blood cell.

"i've always been in 13(敬畏) of how transcription factors direct complicated events, such as development, in which mammals progress from a single, 14 cell into a complex, three-dimensional organism in a 15 short period of time," leid said. "it's just a beautifully 16(精心设计的) dance, and 17 is everything."

ctip2 seems to be a very top-level regulator of development and differentiation in many different cell types, leid said. it should be possible to develop drugs that decrease, increase or otherwise modify ctip2 activity, and such drugs may be useful in the treatment of certain malignancies(恶性肿瘤) , such as leukemia(白血病) , and skin cancers, he said.



点击收听单词发音收听单词发音  

1 wgkxx     
n.遗传因子,基因
参考例句:
  • a single gene may have many effects.单一基因可能具有很多种效应。
  • the targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。
2 pgixp     
adj.遗传的,遗传学的
参考例句:
  • it's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
3 6e49dcafe3638183c823d3aa5b12b010     
n.混乱( disorder的名词复数 );凌乱;骚乱;(身心、机能)失调
参考例句:
  • reports of anorexia and other eating disorders are on the increase. 据报告,厌食症和其他饮食方面的功能紊乱发生率正在不断增长。 来自《简明英汉词典》
  • the announcement led to violent civil disorders. 这项宣布引起剧烈的骚乱。 来自《简明英汉词典》
4 2c527dd68e63f119442f4352f2a0b950     
n.[医]过敏症;[口]厌恶,反感;(对食物、花粉、虫咬等的)过敏症( allergy的名词复数 );变态反应,变应性
参考例句:
  • food allergies can result in an enormous variety of different symptoms. 食物过敏会引发很多不同的症状。 来自辞典例句
  • let us, however, examine one of the most common allergies; hayfever. 现在让我们来看看最常见的变态反应的一种--枯草热。 来自辞典例句
5 jz4zf     
n.珐琅,搪瓷,瓷釉;(牙齿的)珐琅质
参考例句:
  • i chipped the enamel on my front tooth when i fell over.我跌倒时门牙的珐琅质碰碎了。
  • he collected coloured enamel bowls from yugoslavia.他藏有来自南斯拉夫的彩色搪瓷碗。
6 h3hzt     
n.药房,药剂学,制药业,配药业,一批备用药品
参考例句:
  • she works at the pharmacy.她在药房工作。
  • modern pharmacy has solved the problem of sleeplessness.现代制药学已经解决了失眠问题。
7 rqzzmm     
n.侵略者,侵犯者,入侵者
参考例句:
  • they suffered a lot under the invader's heel.在侵略者的铁蹄下,他们受尽了奴役。
  • a country must have the will to repel any invader.一个国家得有决心击退任何入侵者。
8 dygyq     
n.优惠;免除;豁免,豁免权
参考例句:
  • the law gives public schools immunity from taxation.法律免除公立学校的纳税义务。
  • he claims diplomatic immunity to avoid being arrested.他要求外交豁免以便避免被捕。
9 8vbx6     
adj.显著的,异常的,非凡的,值得注意的
参考例句:
  • she has made remarkable headway in her writing skills.她在写作技巧方面有了长足进步。
  • these cars are remarkable for the quietness of their engines.这些汽车因发动机没有噪音而不同凡响。
10 wuozfs     
n.区别,区分
参考例句:
  • there can be no differentiation without contrast. 有比较才有差别。
  • the operation that is the inverse of differentiation is called integration. 与微分相反的运算叫做积分。
11 6rky6     
n.蓝图,设计图,计划;vt.制成蓝图,计划
参考例句:
  • all the machine parts on a blueprint must answer each other.设计图上所有的机器部件都应互相配合。
  • the documents contain a blueprint for a nuclear device.文件内附有一张核装置的设计蓝图。
12 01914f8eac35d7e14afa065217edd8c0     
n.基因( gene的名词复数 )
参考例句:
  • you have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因,所以能够活得很长。 来自《简明英汉词典》
  • differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学 - 生命科学 - 生物技术的世纪
13 wnqzc     
n.敬畏,惊惧;vt.使敬畏,使惊惧
参考例句:
  • the sight filled us with awe.这景色使我们大为惊叹。
  • the approaching tornado struck awe in our hearts.正在逼近的龙卷风使我们惊恐万分。
14 0f66e269f3e72fa001554304e59712da     
v.施肥( fertilize的过去式和过去分词 )
参考例句:
  • the study of psychology has recently been widely cross-fertilized by new discoveries in genetics. 心理学研究最近从遗传学的新发现中受益匪浅。
  • flowers are often fertilized by bees as they gather nectar. 花常在蜜蜂采蜜时受粉。
15 bkqzs3     
adv.比较...地,相对地
参考例句:
  • the rabbit is a relatively recent introduction in australia.兔子是相对较新引入澳大利亚的物种。
  • the operation was relatively painless.手术相对来说不痛。
16 e69e62ff0b4ac8f0ef92f76df34833c1     
v.设计舞蹈动作( choreograph的过去式和过去分词 )
参考例句:
  • there was some carefully choreographed flag-waving as the president drove by. 总统的车经过时,人们按精心编排的动作挥舞着旗帜。
  • achim had choreographed the dance in act ii himself. 阿希姆自己设计了第2幕的舞蹈动作。 来自辞典例句
17 rguzgc     
n.时间安排,时间选择
参考例句:
  • the timing of the meeting is not convenient.会议的时间安排不合适。
  • the timing of our statement is very opportune.我们发表声明选择的时机很恰当。
tag标签: genetic cell
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