干细胞疗法出现新并发症-凯发k8官网

following stem cell therapy, an adult patient experienced a new and ¹ unrecognized complication（并发症） , which required removal of one of the kidneys, according to a case report（病案报告） appearing in an upcoming issue of the journal of the american society nephrology (jasn). the report suggests that stem cell therapy may cause patients to develop blood ²（血管） and bone ³（骨髓） masses, the long term effects of which are unknown. stem cell therapy holds great clinical potential for a variety of diseases. therapy using stem cells from the blood has generally been viewed as safe, and researchers have planned clinical trials to expand this type of therapy to treat different conditions. however, a new report indicates that a previously undescribed complication may result. the case involves an adult patient with severe kidney（肾脏） disease, who was treated at a private clinic, by direct injection of her own stem cells into her kidneys. after a few months, one kidney developed bleeding and required removal.

duangpen thirabanjasak, md, kavirach tantiwongse, md (chulalongkorn university, in bangkok, thailand) in ⁴ with（经与……磋商） paul scott thorner, md, phd (the hospital for sick children, the university of toronto, in canada and chulalongkorn university) were involved in the removal and analysis of the kidney. they found that the patient had not benefitted from the treatment but, rather, had developed masses called angiomyeloproliferative lesions（损害） at the injection sites composed of a mixture of blood ⁵ and bone marrow cells. the remaining kidney eventually failed, and the patient ultimately died from an infection.

"this type of lesion has never been described before in patients, and we believe that this is either formed directly by the stem cells that were injected or that the stem cells caused these masses to form," said dr. thirabanjasak. she ⁶ that because this was a unique occurrence, no one knows how these lesions might have behaved over time.

the authors conclude that their findings should serve as a warning to clinical ⁷ that the development of blood vessel and bone marrow masses may be a possible complication of stem cell therapy. further research is needed to determine the circumstances that may cause these masses to form and to determine strategies to avoid this possible complication from occurring in the future.

in reviewing the results of this report in an accompanying editorial, andras nagy, phd and susan quaggin, md (mount sinai hospital and the university of toronto) noted that it provides a cautionary note and underscores a growing risk associated with the increased number of private clinics offering stem cell therapies to patients with little or no ⁸ from the scientific stem cell community. "⁹ enthusiasm（热心，热情） and ¹⁰（协议，条款） that are not ^{11 12} are dangerous and result in negative ¹³ for the field of stem cell research, and more importantly, may result in ¹⁴（悲伤的，灾难性的） outcomes with no benefit to the patient," they wrote.