亨廷顿疾病防治研究取得重大突破-凯发k8官网

亨廷顿疾病防治研究取得重大突破
文章来源:未知 文章作者:meng 发布时间:2010-05-24 06:27 字体: [ ] 
(单词翻译:双击或拖选)

they might not be known for their big brains, but fruit flies are 1 to make scientists and doctors smarter about what causes huntington's disease and how to treat it. new research, published in the journal genetics (http://www.genetics.org) describes a laboratory test that allows scientists to evaluate large numbers of fruit fly 4 for a possible role in the formation of 5(血小板) -like protein 7(总量,合体) within cells. those genes often have counterparts in humans, which might then be manipulated to stop or slow the formation of plaque-like protein aggregates, the hallmark(特点) of huntington's and several other neurodegenerative(神经变性的) diseases. "6 formations are closely linked to aging and brain diseases," said sheng zhang, ph.d, a researcher involved in the work from the research center for neurodegenerative diseases, the brown foundation institute of 8 medicine, the university of texas health science center at houston. "we hope our study will not only help to uncover how the formation of aggregates is regulated in a cell, but also help find good drug-development targets. then, we can find ways to slow down plaque formations during aging and prevent and treat aggregates-related brain diseases, which are a pressing challenge to a modern society that is enjoying a longer life 9."

to make this advance, scientists examined every known 2 in the fruit fly genome and identified a small group of genes (more than 70 percent of which have human counterparts相对物) that likely play important roles in regulating the formation of plaque-like protein aggregates within cells. they then expressed the huntington's disease protein in the fruit fly and found that it caused plaque-like protein aggregates in different fly tissues, including the brain and in cultured cells. the plaque-like protein aggregates were similar in appearance and biochemical properties(性能,道具) to those found in tissues of people with huntington's disease. the scientists employed two methods to survey a large number of genes: 10 microscopy(显微镜使用) for imaging the plaque-like protein aggregates in the cells at a high-magnification level, and a computer-assisted method to quantify information on the aggregates in each tested sample. by integrating(整合,集成化) these methods, researchers were able to quickly examine all the approximately 14,000 fruit fly genes and identify the ones that are important for regulating the formation of aggregates by the mutant(突变的) huntington protein.

"the 3 11(重叠,重复) between humans and fruit flies continues to be a treasure 12(无主珍宝) for scientific discoveries," said mark johnston, editor-in-chief of genetics. "one hundred years ago, no one would have ever thought that research on a fly's brain could lead to medicines for human brains, but this research is a perfect example of this possibility."



点击收听单词发音收听单词发音  

1 2rgzdc     
n.食物的一份&adj.帮助人的,辅助的
参考例句:
  • the poor children regularly pony up for a second helping of my hamburger. 那些可怜的孩子们总是要求我把我的汉堡包再给他们一份。
  • by doing this, they may at times be helping to restore competition. 这样一来, 他在某些时候,有助于竞争的加强。
2 wgkxx     
n.遗传因子,基因
参考例句:
  • a single gene may have many effects.单一基因可能具有很多种效应。
  • the targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。
3 pgixp     
adj.遗传的,遗传学的
参考例句:
  • it's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
  • each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
4 01914f8eac35d7e14afa065217edd8c0     
n.基因( gene的名词复数 )
参考例句:
  • you have good genes from your parents, so you should live a long time. 你从父母那儿获得优良的基因,所以能够活得很长。 来自《简明英汉词典》
  • differences will help to reveal the functions of the genes. 它们间的差异将会帮助我们揭开基因多种功能。 来自英汉非文学 - 生命科学 - 生物技术的世纪
5 v25zb     
n.饰板,匾,(医)血小板
参考例句:
  • there is a commemorative plaque to the artist in the village hall.村公所里有一块纪念该艺术家的牌匾。
  • some latin words were engraved on the plaque. 牌匾上刻着些拉丁文。
6 ckoye     
adj.总计的,集合的;n.总数;v.合计;集合
参考例句:
  • the football team had a low goal aggregate last season.这支足球队上个赛季的进球总数很少。
  • the money collected will aggregate a thousand dollars.进帐总额将达一千美元。
7 46710fe77f663864a23e02a880a9ae53     
数( aggregate的名词复数 ); 总计; 骨料; 集料(可成混凝土或修路等用的)
参考例句:
  • snowflakes are loose aggregates of ice crystals. 雪花是冰晶的松散凝结。
  • our airplanes based in europe should be included in the aggregates. 我们驻欧飞机应包括在总数内。
8 me9xh     
adj.分子的;克分子的
参考例句:
  • the research will provide direct insight into molecular mechanisms.这项研究将使人能够直接地了解分子的机理。
  • for the pressure to become zero, molecular bombardment must cease.当压强趋近于零时,分子的碰撞就停止了。
9 tlmys     
n.期望,预期,(根据概率统计求得)预期数额
参考例句:
  • japanese people have a very high life expectancy.日本人的平均寿命非常长。
  • the atomosphere of tense expectancy sobered everyone.这种期望的紧张气氛使每个人变得严肃起来。
10 fybzf9     
a.自动化的
参考例句:
  • the entire manufacturing process has been automated. 整个生产过程已自动化。
  • automated highway system (ahs) is recently regarded as one subsystem of intelligent transport system (its). 近年来自动公路系统(automated highway system,ahs),作为智能运输系统的子系统之一越来越受到重视。
11 tkixw     
v.重叠,与…交叠;n.重叠
参考例句:
  • the overlap between the jacket and the trousers is not good.夹克和裤子重叠的部分不好看。
  • tiles overlap each other.屋瓦相互叠盖。
12 5piyp     
n.被发现的东西,收藏的东西
参考例句:
  • he assembled a rich trove of chinese porcelain.他收集了一批中国瓷器。
  • the gallery is a treasure trove of medieval art.这个画廊是中世纪艺术的宝库。
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