sharks, skates, and rays are oddities among the fish: they have
1 growing out of the gill arch, a small cradle of bones that supports the gills. this anatomical
2 has led to the proposal that the paired limbs of humans, and before that the paired
3 of fish, evolved from the
4 of gill arches in early fish.
6 evidence for this theory is offered in a new study led by j. andrew gillis, a royal society university research fellow at the university of cambridge, u.k., and a whitman center scientist at the
7 biological laboratory (mbl) in woods hole, mass.
the study, published this week in development, demonstrates striking similarities in the genetic
8 used to pattern gill arch appendages (called branchial rays) and fins/limbs.
studying
9 of the little skate, gillis focused on the
5 sonic hedgehog, which produces a signaling protein whose function is well understood in the mammalian limb.
10, he found that sonic hedgehog's role in branchial rays closely parallels its role in the limb: it sets up the
11 of development and, later, maintains growth of the limb skeleton.
"the shared role of sonic hedgehog in patterning branchial rays and limbs may be due to a deep
12 relationship between the two," gillis says, "or it may simply be that two unrelated appendages independently use the same gene for the same function."
13 studies comparing the function of other
14 during branchial ray and fin/limb development will help to resolve this. gillis will continue his research at the mbl this summer using skates collected and supplied by the marine resources department.
"branchial rays will figure prominently in the story of the evolutionary origin of vertebrate animal appendages, either by shedding light on the evolutionary antecedent of paired fins/limbs, or by teaching us about the genetic
15 that animals can use to invent new appendages," gillis says.
收听单词发音 
